Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect

The effect of mesoporous silica nanoparticles loaded with epirubicin on drug-resistant cancer cells

Objective (s): In chemotherapy for cancer treatment, the cell resistance to multiple anticancer drugs is the major clinical problem. In the present study, mesoporous silica nanoparticles (MSNs) were used as a carrier for epirubicin (EPI) in order to improve the cytotoxic efficacy of this drug against the P-glycoprotein (P-gp) overexpressing cell line. Materials and Methods: MSNs with phosphonat...

pore-expanded mesoporous silica nanoparticles for PET

Larissa Miller,1 Gordon Winter,2 Benjamin Baur,2 Barbara Witulla,2 Christoph Solbach,2 Sven Reske,2,* Mika Lindén1,* 1 Department of Inorganic Chemistry II, University Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany 2 Clinic for Nuclear Medicine, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm, Germany Corresponding author e-mail addresses: [email protected], [email protected]

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One...

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release ...

Live-cell imaging of drug delivery by mesoporous silica nanoparticles